Nose

HOCL Nasal Spray

1. Yu, Park et al. (2011). "The effect of a low concentration of hypochlorous acid on rhinovirus infection of nasal epithelial cells." Am J Rhinol Allergy 25(1): 40-44.

 “Low concentrations of hypochlorous acid (HOCl) have been shown to exhibit both antibacterial and anti-influenza virus activity. To model the antiviral effect of nasal irrigation with low-level HOCl in patients with the common cold, we tested the effects of a low concentration of HOCl on HRV infection of primary human nasal epithelial cells (HNEC). HOCl treatment significantly inhibited HRV-induced secretion of IL-6 and IL-8 and significantly reduced viral titer. The effects of HOCl peaked at 1 minute after HOCl generation and decreased thereafter. These in vitro findings indicate that nasal irrigation with low-level HOCl solution may improve clinical symptoms in patients with the common cold”

2.  Effects of a low concentration hypochlorous Acid nasal irrigation solution on bacteria, fungi, and virus

Kim, Lee et al. (2008). "Effects of a low concentration hypochlorous Acid nasal irrigation solution on bacteria, fungi, and virus." Laryngoscope 118(10): 1862-1867.

“Low concentrations of hypochlorous acid may be used as a nasal irrigation solution. The study evaluated bactericidal, fungicidal, and virucidal effects by challenging the cells with the following microorganisms Aspergillus fumigatus, Haemophilus influenzae, Klebsiella pneumoniae, Rhizopus oryzae, Candida albicans, Methicillin-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes. To study the virucidal effects of HOCl, we used the human influenza A virus. More than 99% of bactericidal or fungicidal activity was noted for all species, except for Candida albicans”

 

Allergy Symptoms Relief and Respiratory Diseases

1. Improved outcomes after low-concentration hypochlorous acid nasal irrigation in pediatric chronic sinusitis

Cho, Min et al. (2016). "Improved outcomes after low-concentration hypochlorous acid nasal irrigation in pediatric chronic sinusitis." Laryngoscope 126(4): 791-795.

“We aimed to evaluate the effectiveness of low-concentration hypochlorous acid (HOCl) nasal irrigation compared to isotonic normal saline for pediatric chronic rhinosinusitis. Total symptom, X-ray scores significantly improved with HOCl. Nasal irrigation with HOCl is an effective adjuvant treatment compared to isotonic normal saline for pediatric sinusitis”

2. Super-oxidized solution inhibits IgE-antigen-induced degranulation and cytokine release in mast cells Medina-Tamayo, et.al. Super-oxidized solution inhibits IgE-antigen-induced degranulation and cytokine release in mast cells. International Immunopharmacology 7 (2007) 1013–1024.

“In summary, our data suggest that HOCL is able to inhibit the cell machinery for granule secretion without altering the main signal transduction pathway induced by IgE-antigen receptor rosslinking. This is a relevant finding because the identification of the mechanism(s) of action of HOCL on mast cells could help to identify novel targets in the intricate pathways that control allergic and inflammatory reactions.”